New Technique to Measure Xanthone in Mangosteen

Researchers established a credible scientific method for testing and measuring xanthones. Preliminary results from a separate study conducted on XanGo Juice, indicate usage of the whole mangosteen fruit as a delivery vehicle leads to high xanthone absorption.

XanGo, LLC, recognized creator of the mangosteen supplement category is leading scientific exploration of the whole mangosteen fruit (Garcinia mangostana) through a tiered approach based on safety, standardization and efficacy.

"These two studies put into context how to measure xanthones and how to effectively absorb these phytonutrients," said Edward Walker, Ph.D., of Weber State University, lead researcher on the published study. "A xanthone measurement standard is in place. Now claims concerning xanthone quantity and efficacy can be evaluated through credible research.”

Published study sets xanthone measurement standard In the peer-reviewed method for quantifying xanthones from the mangosteen fruit, Walker used the high performance liquid chromatography (HPLC) analysis to create an analytical method that accurately identifies xanthones from the rind of the mangosteen fruit.

According to Walker, an 80:20 acetone/water mixture was used to extract the xanthones from dried, ground whole mangosteen fruit rind.

“A total of six xanthones were purified by preparative HPLC, utilizing the same solvent system and UV detection as for the analytical method,” said Walker. “Each compound has unique UV absorption spectra that allows for easy identification of the xanthone found naturally in the mangosteen fruit."

Research lab ChromaDex developed the standards, and in accordance with AOAC protocol, performed a single lab validation to quantify xanthones through comparison measurement of detector response factors of individual xanthones. Walker said the research team chose the whole mangosteen fruit rind as the starting point because it holds the highest concentration of xanthones in their natural, unaltered state.