Skin Cancer may be Prevented by Chronic Inflammation

Scientists have found that inflammation can actually prevent skin cancer after studying an animal model of chronic inflammation and skin cancer.

Inflammation is the frontline defence of the body against infection or disease.

According to researchers at Medical College of Georgia, IDO, an enzyme that works like a firefighter to keep inflammation under control, can be captured to protect early malignant cells

"Inflammation should really help prevent a tumour. You want a good immune response; this is what protects you from pathogens," he says. "In this case, it's an unfortunate exploitation by malignant cells," says Dr. Andrew Mellor, director of the MCG Immunotherapy Center and Georgia Research Alliance Eminent Scholar in Molecular Immunogenetics.

In fact, the researchers found strong evidence that inflammation triggers the immune response.

In the study, the researchers gave mice a single dose of a carcinogen right at the moment when they started painting a tiny portion of skin with a poison ivy derivative twice weekly for 20 weeks.

The mix quickly produced IDO and created a "suppressive" immune response that helped resulting precancerous cells grow into tumors. However, employing the same protocol in a mouse in which IDO had been genetically deleted, dramatically slowed tumour development.

The significance of the new study is that the researchers have shown that IDO, or indoleomine 2,3-dioxygenase, may be produced as a part of the inflammatory mix, which could then protect the malignant skin cells.